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  • The Loss of Heterozygosity of FHIT Gene in Sporadic Breast Cancer

    Lisiane Silveira Zavalhia, Andrea Pires Souto Damin, Grasiela Agnes, Aline Weber, Taís Frederes Kramer Alcalde, Laura Marinho Dorneles, Guilherme Watte, Adriana Vial Roehe
    33-39

    Article ID: 3632
    211  (Abstract) 153  (Download)

    Abstract:

    The loss of heterozygosity (LOH) is a genetic event that can change gene function. FHIT is a potential tumor suppressor gene.  Although the precise FHIT molecular mechanism of action is not well understood, evidences suggest that Fhit protein reduced levels are involved in mammary carcinogenesis.  The aim of this study was to investigate if FHIT LOH could influence on sporadic breast... More

    2021-09-13
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