Unleashing the Potential of Stem Cell Bioengineering: From Bench to Bedside and Beyond
Abstract
This paper explores the transformative impact of bioengineering on stem cell research and its journey from experimental models to clinical therapies. We review key innovations such as biomimetic scaffolds, gene-editing tools, bioprinting technologies, and engineered microenvironments that have enhanced the viability, differentiation, and therapeutic efficacy of stem cells. The discussion also addresses major challenges including immunogenicity, manufacturing scalability, and regulatory complexities. By examining recent clinical advancements and translational studies, the paper highlights how interdisciplinary collaboration is bridging the gap between laboratory breakthroughs and real-world treatments. Furthermore, we envision future directions where AI integration, personalized biomaterials, and next-generation tissue engineering techniques will drive the next wave of regenerative medicine and stem cell-based therapies.