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Found 3 items.

  • Association of Genetic Polymorphism of GSTM1 and GSTT1 with the Susceptibility to Antituberculosis Drug-induced Hepatotoxicity in Chinese Population

    Donglin Zhu, Yun Xi, Changzhi Xu, Biji Zou, Jing Huang, Hua Li, Gang Xiao
    80-83

    Article ID: 56
    401  (Abstract) 114  (Download)

    Abstract: Objective To investigate the relationship between the polymorphism of glutathione S transferase M1, T1(GSTM1, GSTT1) gene and the susceptibility to antituberculosis drug induced hepatotoxicity (ATDH) in patients with tuberculosis. Methods GSTM1 and GSTT1 gene polymorphisms in patients with or without liver toxicity after antituberculous treatment were analyzed using multiple PCR method. Results In ATDH... More

    2018-09-04

  • NAT2 Involed in the Susceptibility to Antituberculosis Drug-Induced Liver Injury

    Donglin Zhu, Changzhi Xu, Zhizhi Xie, Gang Xiao, Yun Xi
    6-11

    Article ID: 754
    227  (Abstract) 86  (Download)

    Abstract: Objective: To investigate whether the N-acetyltransferase 2 (NAT2) gene is involved in the development of susceptibility to antituberculosis drug-induced liver damage (ATDLI) in patients with pulmonary tuberculosis in the Han nationality. Methods: We retrospectively analyzed 300 cases of tuberculosis patients without liver damage (control group) and 221 cases of tuberculosis patients... More

    2019-07-16

  • Relationship between CYP2E1 Gene Polymorphism and Anti-tuberculosis Drug-induced Liver Injury

    Donglin Zhu, Yun Xi, Jieming Dong, Fanhua Huang, Changzhi Xu, Gang Xiao
    105-109

    Article ID: 289
    373  (Abstract) 168  (Download)

    Abstract:

     Objective: To investigate the relationship between cytochrome P450 E1 (CYP2E1) gene polymorphisms and susceptibility to anti-tuberculosis drug-induced liver damage (ATDLI) in tuberculosis patients in the Chinese Han nationality. Methods: A retrospective analysis was performed on 360 patients with tuberculosis who had liver damage after tuberculosis treatment (case group) and 360 patients with tuberculosis who did... More

    2018-11-22
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