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• Signaling Pathways Associated with Cancer Stem Cells Play a Significant Role in Immunotherapy Resistance

  Yajuan Zhu, Yuwen Zhou, Yao Xie, Pan Song, Xuelei Ma

  1-10

  
  Article ID: 1409
  405  (Abstract) 123  (Download)
  

  Abstract:

  Cancer stem cells (CSCs) are a subpopulation of tumor cells with properties of self-renewal, pluripotency, plasticity, and differentiation, and are associated with various aberrantly stimulated signaling pathways. They are responsible for tumor recurrence, distant metastasis, and drug resistance, thus inducing poor prognosis. Immunotherapy has achieved encouraging results. However, the resistance associated with its clinical application... More

  2019-12-31

• Case Report: Granular Cell Tumor In Breast

  Ruiz Alcaide Estefania, López Carrizosa Maria Concepción, Gutierrez Pantoja M Aranzazu, Arriaga Piñeiro Jesus M

  4-6

  
  Article ID: 1695
  258  (Abstract) 137  (Download)
  

  Abstract:

  Granular cell tumor (GCT) of the breast is an unusual neoplasm, tipically

  benign, it represents between 5-6% of all GCT cases. These tumors are

  more common in middle-aged premenopausal women with a greater pre

  dilection African American race [1]. Nevertheless, there are also cases de

  scribed in men [2-4]. Almost all of them are favorable, the malignant cases

  are uncommon... More

  2020-04-30

• Postoperative Radiotherapy and N2 Non-small Cell Lung Cancer Prognosis: A Retrospective Study Based on Surveillance, Epidemiology, and End Results Database

  Yunbo Zhang, Liping Zheng, Junqi Liu, Jinqiu Li, Jianguang Zhang, Jingjing Ma, Yuxiu Song

  1-7

  
  Article ID: 3513
  286  (Abstract) 133  (Download)
  

  Abstract: The purpose of this study is to clarify the significance of postoperative radiotherapy for N2 lung cancer. This study aimed to investigate the effect of postoperative radiotherapy on the survival and prognosis of patients with N2 lung cancer. Data from 12,000 patients with N2 lung cancer were extracted from the Surveillance, Epidemiology, and End Results... More

  2021-08-16

• Postoperative UFT-/Tegafur-based Chemotherapy Versus Postoperative Radiotherapy for Early-stage Non-small Cell Lung Cancer：A Systematic Review and Network Meta-analysis

  Lixin Yu, Mi Song, Shuaifei Ji

  11-18

  
  Article ID: 1493
  328  (Abstract) 95  (Download)
  

  Abstract:

  Background: Both of UFT-/Tegafur-based postoperative chemotherapy and postoperative radiotherapy have made large progress in treatment of early-stage non-small cell lung cancer. While it is unclear that, whether UFT-/Tegafur-based postoperative chemotherapy is superior to postoperative radiotherapy for early-stage non-small cell lung cancer with no direct evidence. Methods: Electronic databases (Pubmed, embase, cochrane library and clinicaltrials.gov) were searched to... More

  2019-12-31

• The Loss of Heterozygosity of FHIT Gene in Sporadic Breast Cancer

  Lisiane Silveira Zavalhia, Andrea Pires Souto Damin, Grasiela Agnes, Aline Weber, Taís Frederes Kramer Alcalde, Laura Marinho Dorneles, Guilherme Watte, Adriana Vial Roehe

  33-39

  
  Article ID: 3632
  211  (Abstract) 153  (Download)
  

  Abstract:

  The loss of heterozygosity (LOH) is a genetic event that can change gene function. FHIT is a potential tumor suppressor gene.  Although the precise FHIT molecular mechanism of action is not well understood, evidences suggest that Fhit protein reduced levels are involved in mammary carcinogenesis.  The aim of this study was to investigate if FHIT LOH could influence on sporadic breast... More

  2021-09-13

• High Grade Muscle-Invasive Urinary Bladder Cancer in A 36 Year Old Male Patient: A Case Report & Review of Literature

  Sachin S Kadam, Rohan Jagtap, Tejaswini Kadam

  16-19

  
  Article ID: 3866
  243  (Abstract) 135  (Download)
  

  Abstract:

  We are reporting a case of urothelial bladder cancer in a 36 year old male patient with no history or exposure to any risk factors. The incidence of urothelial bladder cancer is very low in young individuals i.e. below 40 years of age with reported rate of incidence around 0.1-0.4 %. Most of the times,... More

  2021-11-23

• Spectrum of Pediatric Malignancies: An Observational Single Center Study from Western India

  Aditi Mittal, Kanu Neemawat, Sandeep Jasuja, Anushree Chaturvedi

  28-32

  
  Article ID: 3645
  283  (Abstract) 139  (Download)
  

  Abstract: Cancer is a leading cause of death for children and adolescent worldwide. The cure rates in low middle-income countries are dismal (20%) in comparison to high income countries (80%). The first move is to assemble precise data on epidemiology of pediatric cancer across the country and its region wide variation. This study attempts to provide... More

  2021-09-10

• Schistosomal Colorectal Cancer: Biomarkers and Treatment Strategies

  Hytham K. S. Hamid

  19-23

  
  Article ID: 1549
  315  (Abstract) 116  (Download)
  

  Abstract:

  About 15.4% of human cancers worldwide have been attributed to infections. Among these, blood and liver flukes, notably Schistosoma sp, Clonorchis Sinesis, and Opisthorchis Viverrini have been associated with the development of various cancer types. Schistosoma sp. promotes colorectal cancer (CRC) progression through multiple mechanisms including production of toxins, symbiotic action with bacterial agents, and more importantly chronic inflammation. Diagnosis... More

  2019-12-31

• Lead to Elevate the Temperature and Speed of Emergency Rescue and Nursing Care of Common Carotid Artery Rupture and Massive Hemorrhage after Operation of Typical Esophageal Cancer

  Li Fan, Xiaohua Tang, Yuqin Cui

  36-40

  
  Article ID: 2480
  318  (Abstract) 153  (Download)
  

  Abstract:

  Objective: Objective To explore the first aid and nursing of patients

  with anastomotic fistula after radical resection of esophagus carcinoma

  complicated with major carotid hemorrhage. Methods: The clinical data

  of anastomotic fistula complicated with carotid artery rupture and massive

  hemorrhage after radical resection of typical esophageal carcinoma were

  analyzed and summarized. Results: Through the close cooperation of

  medical care, the rescue... More

  2020-11-13

• Paracelsus Paradox and Drug Repurposing for Cancer

  Tomas Koltai

  46-54

  
  Article ID: 3649
  259  (Abstract) 143  (Download)
  

  Abstract:

  Dose is one of the parameters that any pharmacologist seriously considers when studying the effects of a drug. If the necessary dose to achieve a desired pharmacological effect is in a toxic or very toxic range for human use, the drug will probably fall out from further research. The concentration that a drug can reach... More

  2021-09-13

• Measurement of AhR Ligands in the Tissues of Colon Cancer Patients with XRE Luciferase Reporter

  Margarita A Bystriakova, Sergei A Koshkin, Elena N Tolkunova

  3-9

  
  Article ID: 410
  394  (Abstract) 142  (Download)
  

  Abstract:

  The Aryl hydrocarbon receptor (AhR) ligands exhibiting modulating activity represents a new class of anticancer agents that can be directed towards several tumors. We have examined AhR expression in human colon cancer and adjacent non-tumor tissue. AhR expression level was about 2-7 times higher in tumor tissue samples than in the adjacent non-tumor samples (in... More

  2019-07-05

• Associations between Body Mass Index and Breast Cancer Markers

  Ishita Saha, Poonam Singh, Sunit Kumar Medda, Rabindra Nath Das

  1-7

  
  Article ID: 2007
  470  (Abstract) 122  (Download)
  

  Abstract:

  Body mass index (BMI) and breast cancer biomarkers (BCBs) such as

  resistin, leptin adiponectin, monocyte chemoattractant protein-1 (MCP-1)

  and homeostasis model assessment of insulin resistance (HOMA-IR) are

  highly associated with each other. The report has focused the inter-rela

  tionship between BMI and BCBs based on probabilistic modeling. It has

  been shown that mean BMI is directly associated with leptin (P<0.0001)

  and... More

  2020-07-03

• Machine Learning Algorithms for Breast Cancer Diagnosis: Challenges, Prospects and Future Research Directions

  Rebecca Nyasuguta Arika, Agnes Mindila, W. Cheruiyo

  
  Article ID: 4977
  437  (Abstract) 398  (Download)
  

  Abstract:

  Early diagnosis of breast cancer does not only increase the chances of survival but also control the diffusion of cancerous cells in the body. Previously, researchers have developed machine learning algorithms in breast cancer diagnosis such as Support Vector Machine, K-Nearest Neighbor, Convolutional Neural Network, K-means, Fuzzy C-means, Neural Network, Principle Component Analysis (PCA)... More

  2022-11-02

• Unusual Metastases to Diaphragm and Spleen from Adenocarcinoma of Lung Detected by 18F-FDG PET/CT Imaging: A Case Report

  Anindita Rani Paul, Rajib Paul Chowdhury, Pritam Saha Podder, Umme Saoda

  1-3

  
  Article ID: 1586
  313  (Abstract) 126  (Download)
  

  Abstract:

  Globally, carcinoma of lung is the predominant cause of cancer death

  among both men and women. While hematogenous spread from primary

  lung cancer to multiple other organs is frequently reported, metastases of

  malignant tumors to diaphragm and spleen are rare. Nowadays, Positron

  emission tomography (PET) with 18 F- fluorodeoxyglucose (FDG) has

  emerged in such a way that it has become... More

  2020-04-17

• Electrified Water as a Regulator of Cell Proliferation

  Yuri Pivovarenko

  1-10

  
  Article ID: 2742
  310  (Abstract) 161  (Download)
  

  Abstract:

  It was previously found that the electric charge of water determines its ability to interact with other substances, including biologically significant ones. It is shown here that the electric charge of water can also determine its ability to penetrate and accumulate in living cells. In particular, it has been shown that the high penetrating ability of positively charged water determines both its active... More

  2021-02-10

• Potential Phytochemicals for Cancer Treatment: A Review

  Sa’adatu M. Ibrahim, Muhammad Ali, Fauziyya Aminu, Lurwan Mu’azu

  9-15

  
  Article ID: 3656
  391  (Abstract) 219  (Download)
  

  Abstract:

  Today, cancer had been described as one of the deadliest diseases worldwide. It has been estimated that cancer causes about 9.9 million deaths in the year 2020. The conventional treatment for the disease involves single chemotherapy or a combination of mono-chemotherapy and or a combination of mono-chemotherapy and radiotherapy. However, there are negative sides... More

  2021-12-07

• Progress in diagnosis and treatment of basal cell carcinoma

  Yan Liu, Mengxian Ren, Youfei Zhao, Dong Liu, Fei Zhou

  11-12

  
  Article ID: 2038
  360  (Abstract) 88  (Download)
  

  Abstract:

  Basal cell carcinoma is a common skin carcinogenesis that occurs in the epidermis and the basal layer of the skin.in general, basal cell carcinoma grows slowly, rarely metastasizes, but is locally invasive and destructive. The diagnosis is based on clinical manifestations, but the clinicopathological manifestations are different, and sometimes it is difficult to differentiate from... More

  2020-07-03

• Relationship between D90 and D100 with Biochemical and Local Failure in Low-risk Prostate Cancer Treated with Low-rate Brachytherapy (LDR)

  Marta Dominguez Morcillo, Carmen Ibáñez Villoslada, Joaquín Navarro Castellón, Paula Sáez Bueno, Eliseo Carrasco Esteban, Andrea Matas Escamillas, Zigor Zalabarría Zarrabeitia, María Concepción López Carrizosa

  1-12

  
  Article ID: 4721
  151  (Abstract) 135  (Download)
  

  Abstract:

  Low dose rate brachytherapy (LDR) is an accepted, effective treatment with few local side effects, used as monotherapy in patients with low-risk prostate cancer (PC). The aim of this paper is to analyse 245 patients treated with LDR in the Radiation Oncology Department of the Hospital Gómez Ulla, from 2004 to 2016, evaluating the relationship... More

  2022-08-19