Meta-Analysis on Efficacy of Vaccination against Staphylococcus aureus and Escherichia coli

Authors

  • Ziyang Fu Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China;College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
  • Haikun Liu Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China;College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
  • Hong Cao Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China;College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
  • Yongqiang Wang Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China;College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China

DOI:

https://doi.org/10.30564/vsr.v2i1.1929

Abstract

Mastitis is a common disease responsible for the biggest economic loss in the dairy industry. Antibiotic therapy does not provide long-term protection. And residue is a major concern in food safety. Vaccination is an alternative control method with great potential for bovine mastitis. Our study focus on evaluating vaccine efficacy regarding reducing the incidence of clinical and subclinical mastitis. Meta-analysis was used to pool data extracted from previous studies. 26 records from 13 studies were examined. A fixed effect model was constructed assigning incidence as the measurement of the outcome. Risk ratio (RR) was the parameter that measured the incidence differences between treated group and control group. Studies and records were categorised based on vaccine antigens. In vaccine against Staphylococcus aureus, RR was 0.76; 95% CI (0.65,0.89), while in vaccine against Escherichia coli RR was 0.96; 95% CI (0.86,1.08).

Keywords:

Bovine mastitis; Vaccination; Meta-analysis

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Vol. 2 , Iss. 1 (June 2020)

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