Effects of Exercise on the Pharmacokinetics of Icariin II in Rats

Authors

  • Xiliang Kong College of Physical Education, Qufu Normal University

DOI:

https://doi.org/10.30564/jams.v2i1.161

Abstract

High performance liquid chromatography (HPLC) was established to determine the concentration of Icariin II in rats. The time-dependent changes in rats after taking Icariin II were studied, and the main pharmacokinetic parameters were obtained. The main pharmacokinetic parameters of taking the medicine in a quiet state, taking the medicine after half an hour of exercise and taking the medicine after long-term exercise were compared to verify whether the absorption and utilization of the Icariin II were more favorable in the exercise state; The paper has important guiding significance for guiding athletes to safe medication and further development of this drug.

Keywords:

Icariin II; Exercise state; High performance liquid chromatography

References

[1] Zuozhou Li, Yanqin Xu, Ying Wang, etc. Research status and prospects of Epimedium medicinal plants[J].Chinese Herbal Medicine, 2005, 36 (2). (in Chinese)

[2] Xin Ji. Research progress on immunomodulatory effects of Icariin[J]. Hebei Medical Journal, 2016 (5): 753-756. (in Chinese)

[3] GUO B L XIAO PG. Comment on main species of Herb Epimedium[J]. China Journal of Chinese Matera Medico, 2003, 28(4). (in Chinese)

[4] Jinxiao Shi, Cheng Dian. Study on leaf anatomical structure of Epimedium sagittatum in different populations[J].Life Science Research, 2005, 9 (4). (in Chinese)

[5] Hongming Nie, Rong Wang, et al. Experimental study on liver-protecting and choleretic treatment of Epimedium decoction and Icariin II[J].Journal of Practical Chinese Medicine, 2006, 20(4). (in Chinese)

[6] Erxin Shang, Xinsheng Fan, Yuping Tang, et al. Study on the variation of prescription and dosage of “Golden Chamber” [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2009, 25(1). (in Chinese)

[7] Yifan Zhou, Changjiang Hu, et al. Pharmacokinetics of Epimedium in rats before and after processing[J].Chinese Patent Medicine, 2013, 12. (in Chinese)

[8] Xiwei Zhang, Yingping Chen,et al. LC-MS/MS method for the detection of plasma Icariin in healthy humans and its pharmacokinetic study[J].Liaoning Journal of Traditional Chinese Medicine, 2014, 1. (in Chinese)

[9] P Xue, X Wu, L Zhou, H Ma. IGF1 promotes osteogenic differentiation of mesenchymal stem cells derived from rat bone marrow by increasing TAZ expression[J]. Biochemical & Biophysical Research Communications, 2013, 433 (2): 226-231. (in Chinese)

Downloads

Issue

Vol. 2 , Iss. 1 (January 2019)

Article Type

Research Article

License

Copyright and Licensing

The authors shall retain the copyright of their work but allow the Publisher to publish, copy, distribute, and convey the work.

Journal of Advances in Medicine Science publishes accepted manuscripts under Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). Authors who submit their papers for publication by Journal of Advances in Medicine Science agree to have the CC BY-NC 4.0 license applied to their work, and that anyone is allowed to reuse the article or part of it free of charge for non-commercial use. As long as you follow the license terms and original source is properly cited, anyone may copy, redistribute the material in any medium or format, remix, transform, and build upon the material.

License Policy for Reuse of Third-Party Materials

If a manuscript submitted to the journal contains the materials which are held in copyright by a third-party, authors are responsible for obtaining permissions from the copyright holder to reuse or republish any previously published figures, illustrations, charts, tables, photographs, and text excerpts, etc. When submitting a manuscript, official written proof of permission must be provided and clearly stated in the cover letter.
The editorial office of the journal has the right to reject/retract articles that reuse third-party materials without permission.

Journal Policies on Data Sharing

We encourage authors to share articles published in our journal to other data platforms, but only if it is noted that it has been published in this journal.