Isolates of Cryptococcus Neoformans from Non-HIV and Non-Transplant Hospitalized Patients

Authors

  • Yun Xi Dept. of Lab., 3rd Affil. Hosp. of Zhongshan Uni., Guangzhou, Guangdong, 510630, China
  • Peng Zhao Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong, 510630, China
  • Ling Tao Dept. of Parm., 3rd Affil. Hosp. of Zhongshan Uni., Guangzhou, Guangdong
  • Jing Huang Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong
  • Youming Chen Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong
  • Yongmei Fu Dept. of Emergency, 3rd Affil. Hosp. of Zhongshan Uni., Guangzhou, Guangdong
  • Hengbiao Sun Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong
  • Xu You Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong
  • Gang Xiao Dept. of Lab., 3rd Affil. Hosp. of S. Med. Uni., Guangzhou, Guangdong

DOI:

https://doi.org/10.30564/jams.v1i2.36

Abstract

A retrospective cross-sectional study for patients with confirmed Cryptococcus neoformans meningitis (CM) in non-HIV-infected and non-transplant hosts in two class-A tertiary hospitals in Guangzhou, China is reported. 181 CM patients were enrolled during the study period, 48% (87/181) of which died. Underlying diseases were risk factor associated with higher mortality, among which diabetes mellitus ranked first for the incidence of CM. The mortality was not related to antifungal drug susceptibility. All strains were considered susceptible to amphotericin B, although interpretative breakpoints for amphotericin B have not yet been established. According to the CLSI guidelines, most of the strains in our study were susceptible to voriconazole, fluconazole, fluorocytosine and dose-dependently susceptible to itraconazle.

Keywords:

Cryptococcus neoformans; Drug resistance; Nosocomial infection

References

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Issue

Vol. 1 , Iss. 2 (July 2018)

Article Type

Research Article

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