Victoria Serhiyenko
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine
Krystina Kozlovska
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine
Alexandr Serhiyenko
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine
Objective: Relevance of cardiac autonomic neuropathy has not been fully recognized and there is no standardized treatment protocol.Aim: To evaluate the effects of alpha-lipoic acid on the beat-to-beat vectorcardiographic parameters, namely spatial QRS-T angle, QT dispersion (QTd) and corrected QT interval (QTc) in type 2 diabetes mellitus persons with cardiac autonomic neuropathy. Research designs and methods: Our study involved 33 persons with definite stage of cardiac autonomic neuropathy and diabetes mellitus type 2, which were assigned to each of two groups: one took standard antihyperglycaemic treatmen (n=15, control group) and the other (n=18) in addition to standard therapy - 600 mg of alpha-lipoic acid daily for three months. The analysis of vectorcardiographic parameters was performed. Results: It was found out that alpha-lipoic acid contributed to decrease of the vectorcardiographic parameters, namely QRS-T angle, QTd and QTc. Conclusions: The positive influences of alpha-lipoic acid suggest the usefulness of its prescription to type 2 diabetes mellitus persons with definite stage of cardiac autonomic neuropathy. The efficacy of alpha-lipoic acid is the result of its direct effect on the parameters of vectorcardiography.
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Aims and Scope