Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome


  • Manoj Gedam Department of Endocrinology, Guwahati Medical College, Assam, India
  • Dipti Sarma Department of Endocrinology, Guwahati Medical College, Assam, India
  • Bipul Choudhury Department of Endocrinology, Guwahati Medical College, Assam, India




To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p<0.01),stimulated serum C peptide (p<0.01), serum fasting insulin (p<0.01) and HOMA IR (p<0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR >2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.


Metabolic syndrome, Insulin resistance, Body mass index, Type 2 diabetes mellitus


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How to Cite

Gedam, M., Sarma, D., & Choudhury, B. (2021). Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome. Journal of Endocrinology Research, 3(2), 1–9. https://doi.org/10.30564/jer.v3i2.3451


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