Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

Authors

  • Manoj Gedam Department of Endocrinology, Guwahati Medical College, Assam, India
  • Dipti Sarma Department of Endocrinology, Guwahati Medical College, Assam, India
  • Bipul Choudhury Department of Endocrinology, Guwahati Medical College, Assam, India

DOI:

https://doi.org/10.30564/jer.v3i2.3451

Abstract

To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p<0.01),stimulated serum C peptide (p<0.01), serum fasting insulin (p<0.01) and HOMA IR (p<0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR >2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.

Keywords:

Metabolic syndrome; Insulin resistance; Body mass index; Type 2 diabetes mellitus

References

[1] Misra A, Khurana L. Obesity and the Metabolic Syndrome in Developing Countries. J Clin Endocrinol Metab. 2008;93(11_Supplement_1):s9 -30. [PubMed].

[2] D. Prabhakaran, V. Chaturvedi, P. Shah et al., “Differences in the prevalence of metabolic syndrome in urban and rural India: a problem of urbanization,” Chronic Illness, vol. 3, no. 1, pp. 8 -19, 2007.View at: Publisher Site.

[3] A. Misra and L. Khurana, “The metabolic syndrome in South Asians: epidemiology, determinants, and prevention,” Metabolic Syndrome and Related Disorders, vol. 7, no. 6, pp. 497 -514, 2009.View at: Publisher Site | Google Scholar.

[4] John B. Buse, Kenneth S. Polonsky, Charles F. Burant. Type 2 Diabetes Mellitus. In: Williams textbook of endocrinology. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, Henry M. Kronenberg (ed), Elsevier Saunders.12th edi., 2011.chap.31.pp 1371-435.

[5] Gjessing HJ, Matzen LE, Froland A, Faber OK. Correlations between fasting plasma C-peptide, glucagon-stimulated plasma C-peptide, and urinary C-peptide in insulin-treated diabetics. Diabetes Care 1987;10:487-90.

[6] Huttunen NP, Knip M, Kaar ML, Puukka R, Akerblom HK. Clinical significance of urinary C-peptide excretion in children with insulin- dependent diabetes mellitus. Acta paediatrica Scandinavica 1989;78:271-7.

[7] Meistas MT, Zadik Z, Margolis S, Kowarski AA. Correlation of urinary excretion of C-peptide with the integrated concentration and secretion rate of insulin. Diabetes 1981;30:639-43.

[8] Aoki Y. Variation of endogenous insulin secretion in association with treatment status: assessment by serum C-peptide and modified urinary C-peptide. Diabetes Res Clin Pract 1991;14:165-73.

[9] Cote AM, Firoz T, Mattman A, Lam EM, von Dadelszen P, Magee LA. The 24-hour urine collection: gold standard or historical practice? American journal of obstetrics and gynecology 2008;199:625 e1-6.

[10] Beigh SH, Jain S. Prevalence of metabolic syndrome and gender differences. Bioinformation. 2012;8(13):613 -616. DOI: 10.6026/97320630008613.

[11] Prasad DS, Kabir Z, Dash AK, Das BC. Prevalence and risk factors for metabolic syndrome in Asian Indians: A community study from urban Eastern India. J Cardiovasc Dis Res. 2012;3(3):204 -211. DOI: 10.4103/0975-3583.98895.

[12] Ogbera, A.O. Prevalence and gender distribution of the metabolic syndrome. Diabetol Metab Syndr 2, 1 (2010). DOI: 10.1186/1758-5996-2-1.

[13] Prevalence of metabolic syndrome crossing 40% in Northern India: Time to act fast before it runs out of proportions Khan Yasmee, Lalchandani Arati, Gupta Ajesh Chandra, Khadanga Sagar, Kumar Sanjeev.

[14] Thomas, N. J., Shields, B. M., Besser, R. E. J., Jones, A. G., Rawlingson, A., Goodchild, E., … Hattersley, A. T. (2012). The impact of gender on urine C-peptide

[15] creatinine ratio interpretation. Annals of Clinical Biochemistry, 49(4), 363 -368. https://doi.org/10.1258/acb.2011.011164.

[16] Urinary c-peptide and urine c-peptide/creatinine ratio (ucpcr) are possible predictors of endogenous insulin secretion in t2dm subjects - a randomized study kulkarni c m1, sumangala patil2.

[17] Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogeneous Chinese population with normal glucose tolerance a,c, c b * Chen-Huan Chen, Shih-Tzer Tsai, Pesus Chou aDepartment of Social Medicine, National Yang-Ming University, Taipei, Taiwan bCommunity Medicine Research Center,National Yang-Ming University, Taipei, Taiwan cDepartment of Medicine, Veterans General Hospital-Taipei, Taipei, Taiwan.

[18] Oram RA, Rawlingson A, Shields BM, et al. Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study. BMJ Open 2013;3: e003193. DOI: 10.1136/ bmjopen-2013-003193.

[19] Urinary C-Peptide Excretion: A Novel Alternate Measure of Insulin Sensitivity in Physiological Conditions Jose E. Galgani1, Lilian de Jonge1, Jennifer C. Rood1, Steven R. Smith1, Andrew A. Young2 and Eric Ravussin1 Obesity (2010) 18, 1852 -1857. DOI: 10.1038/oby.2010.70.

[20] Correlation of Urinary Excretion of C-Peptide with the Integrated Concentration and Secretion Rate of Insulin MaryT Meistas, Zvi Zadik,Simeon Margolis, A Avinoam KowarskiDiabetes Aug 1981, 30 (8) 639-643.DOI: 10.2337/diab.30.8.639.

[21] Wang Y, Gao Y, Cai X, et al. Clinical Implications of Urinary C-Peptide Creatinine Ratio in Patients with Different Types of Diabetes. J Diabetes Res. 2019;2019:1747684. Published 2019 Aug 7. DOI: 10.1155/2019/1747684.

[22] Pasquali, R., Biso, P., Baraldi, G. et al. Acta diabet. lat (1983) 20: 153. https://doi.org/10.1007/BF02624916.

[23] URINE C-PEPTIDE TEST: A NOVEL NON-INVASIVE TECHNIQUE FOR DIAGNOSIS AND MANAGEMENT OF PATIENTS WITH TYPE-1 DIABETES Pokhriyal BN*, Thorat K, Dubey R, Limaye

[24] DA, Joshi YM and Kadam VJ IJRPC 2012, 2(2).

[25] https://www.researchgate.net/publication/259499343A study of Insulin Resistance by HOMA-IR and its Cut off Value to Identify Metabolic Syndrome in Urban Indian Adolescents.

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Gedam, M., Sarma, D., & Choudhury, B. (2021). Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome. Journal of Endocrinology Research, 3(2), 1–9. https://doi.org/10.30564/jer.v3i2.3451

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