Onur Oral
Faculty of Sports Sciences, Ege University, Izmir, Turkey
Pınar Tatlibal
Necat Hepkon Faculty of Sports Sciences, Dokuz Eylül University, Izmir, Turkey
Evangelia Stavropoulou
Research in Information and Communication, University of Lorraine, France
Background: The study aims to investigate and evaluate the impactof irisin on physical activity and obesity. Materials and Methods: Inthe search for scientific literature related to this review the US NationalLibrary of Medicine (PubMed) used MEDLINE and SportDiscus dataand the terms "irisin", "physical activity", and "obesity", were used. Therelevant literature has also taken its source from the research of relevantarticles from reference lists derived from data studies. Results: Irisin, anemerging myokine in the scientific community, has received high attentionas a potential contributor to obesity. This hormone is also associated withphysical activity. Conclusions: Irisin was recently identified as a myokineknown to respond to physical activity. Adequate recognition of thishormone may play an active role in the prevention and treatment of obesity.
[1] Elder, J.P., 2013. Mexico and the USA: the world’s leaders in the obesity epidemic. Salud Pública México. 55, 355.
[2] González-Gross, M., Gómez-Lorente, J.J., Valtueña, J., et al., 2008. The “healthy lifestyle guide pyramid” for children and adolescents. Nutrición hospitalaria. 23(2), 159-168.
[3] Oral, U., 2020. Political Perception Of Generation Z In Turkey. International Journal of Advanced Science and Technology. 29(11s), 493-500.
[4] Martinez-Gomez, D., Moreno, L.A., Romeo, J., et al., 2011. Combined influence of lifestyle risk factors on body fat in Spanish adolescents-the Avena study. Obesity Facts. 4(2), 105-111.
[5] Boström, P., Wu, J., Jedrychowski, M.P., et al., 2012. A PGC1-α-dependent myokine that drives brownfat-like development of white fat and thermogenesis. Nature. 481, 463-468.
[6] Kraemer, R.R., Shockett, P., Webb, N.D., et al., 2014. A transiently elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Hormone and Metabolic Research. 46(2), 150-154.
[7] Wu, J., Boström, P., Sparks, L.M., et al., 2012. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 150, 366-376.
[8] Pedersen, B.K., Febbraio, M.A., 2012. Muscles, exercise, and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology. 8(8), 457-465.
[9] Elizondo-Montemayor, L., Silva-Platas, C., Torres-Quintanilla, A., et al., 2017. Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity. BioMed Research International. 2628968. DOI: https://doi.org/10.1155/2017/2628968
[10] Jedrychowski, M.P., Wrann, C.D., Paulo, J.A., et al., 2015. Detection and quantitation of circulating human irisin by tandem mass spectrometry. Cell Metabolism. 22(4), 734-740.
[11] Anastasilakis, A.D., Polyzos, S.A., Saridakis, Z.G., et al., 2014. Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition. The Journal of Clinical Endocrinology & Metabolism. 99(9), 3247-3255. DOI: https://doi.org/10.1210/JC.2014-1367
[12] Moreno-Navarrete, J., Ortega, F., Serrano, M., et al., 2013. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 98, E769-E778.
[13] Polyzos, S.A., Kountouras, J., Shields, K., et al., 2013. Irisin: a renaissance in metabolism? Metabolism. 62, 1037-1044.
[14] Boström, P.A., Fernández-Real, J.M., Mantzoros, C., 2014. Irisin in humans: recent advances and questions for future research. Metabolism. 63, 178-180.
[15] Saraslanidis, P., Petridou, A., Bogdanis, G.C., et al., 2011. Muscle metabolism and performance improvement after two training programmes of sprint running differing in rest interval duration. Journal of Sports Sciences. 29, 1167-1174.
[16] Roca-Rivada, A., Castelao, C., Senin, L.L., et al., 2013. FNDC5/irisin is not only a myokine but also an adipokine. PLoS ONE. 8(4), e60563.
[17] Huh, J.Y., Panagiotou, G., Mougios, V., et al., 2012. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism: Clinical and Experimental. 61(12), 1725-1738. DOI: https://doi.org/10.1016/j.metabol.2012.09.002
[18] Norheim, F., Langleite, T.M., Hjorth, M., et al., 2014. The effects of acute and chronic exercise on PGC-1α, irisin, and browning of subcutaneous adipose tissue in humans. Federation of European Biochemical Societies Journal. 281, 739-749.
[19] Fain, J.N., Company, J.M., Booth, F.W., et al., 2013. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism. 62, 1503-1511.
[20] Stengel, A., Hofmann, T., Goebel-Stengel, M., et al., 2013. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity—correlation with body mass index. Peptides. 39(1), 125- 130.
[21] Pardo, M., Crujeiras, A.B., Amil, M., et al., 2014. Association of Irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. International Journal of Endocrinology. Article ID 857270, 9 pages.
[22] Blüher, S., Panagiotou, G., Petroff, D., et al., 2014. Effects of a 1-Year Exercise and Lifestyle Intervention on Irisin, Adipokines, and Inflammatory Markers in Obese Children. Obesity. DOI: https://doi.org/10.1002/oby.20739
[23] Park, K.H., Zaichenko, L., Brinkoetter, M., et al., 2013. Circulating irisin in relation to insulin resistance and the metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism. 98(12), 4899-4907. DOI: https://doi.org/10.1210/jc.2013-2373
[24] Timmons, J., Baar, K., Davidsen, P., et al., 2012. Is irisin a human exercise gene? Nature. 448, E9-E10.
[25] Villarroya, F., 2012. Irisin, turning up the heat. Cell Metab. 15, 277-278.
[26] Liu, J.J., Wong, M.D., Toy, W.C., et al., 2013. Lower circulating irisin is associated with type 2 diabetes mellitus. Journal of Diabetes and Its Complications. 27, 365-369.
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