Factors Affecting Catecholamines in Caregivers of Patients with Dementia


  • Akemi Hirano Department of Adult Nursing, Shubun University, 6 Nikko-cho, Ichinomiya, Aichi 491-0938, Japan
  • Yusuke Suzuki Centre for Community Liaison and Patient Consultations, Nagoya University Hospital, 65 Tsuruma, Showa, Nagoya, Aichi 466-8550, Japan
  • Toshio Hayashi Department of Community and In-Home Nursing, Nagoya University Graduate School of Medicine, School of Health Sciences, Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
  • Koichiro Ina Department of Internal Medicine, Ina Clinic, 3-111 Hirabari, Tenpaku, Nagoya, Aichi 468-0011, Japan
  • Joji Onishi Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma, Showa, Nagoya, Aichi 466-8550, Japan




Background: Caregivers of dementia patients have significantly higher levels of serum IL-6 and CRP compared to non-caregivers, and the accumulation of everyday stressors reportedly promotes the induction of inflammatory markers. However, few studies have identified factors that affect catecholamine levels in caregivers who experience a combination of physical and mental stress from caregiving. Purpose: This study aimed to identify physical factors that impact catecholamine levels in caregivers of dementia patients. Methods: Participants were elderly caregivers living together with elderly Alzheimer’s-type dementia patients. We performed logistic regression analysis, with levels of adrenaline, noradrenaline, and dopamine (indicators of catecholamine) as dependent variables. Results: Caregiver BMI had a significant impact on adrenaline levels (OR: 0.792; 95%CI: 0.654-0.960) and noradrenaline levels (OR: 1.210; 95%CI: 1.009-1.451), whereas age had a significant impact on dopamine levels (OR: 1.162; 95%CI: 1.019- 1.324). Discussion: While caregiver BMI significantly impacted adrenaline and noradrenaline levels, the mechanism underlying these relationships is unclear. One possibility is that obesity (BMI) and a rise in sympathetic nerve activity contributed to hypertension. Our findings suggest that chronic stress in elderly caregivers may potentially impair the dopaminergic activation system in the brain. Conclusion: There is a need to identify factors which increase BMI in caregivers. Future studies aimed at gaining a better understanding of the lifestyle habits of caregivers and intervention studies aimed at reducing their BMI are warranted


Age, BMI, Caregiver burden, Catecholamine, Dementia


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How to Cite

Hirano, A., Suzuki, Y., Hayashi, T., Ina, K., & Onishi, J. (2021). Factors Affecting Catecholamines in Caregivers of Patients with Dementia. Journal of Geriatric Medicine, 3(1), 32–37. https://doi.org/10.30564/jgm.v3i1.2712


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