Report of Lupus Encephalopathy in Two Patients with Systemic Lupus Erythematosus

Authors

  • Mi Mi Zhou

    Department of rheumatology, Hangzhou Wenzhong Hospital, China

  • Baoping Song

    Department of rheumatology, Hangzhou Wenzhong Hospital, China

  • Gang Li

    Department of rheumatology, Hangzhou Wenzhong Hospital, China

  • Zhengyao Peng

    Department of rheumatology, Hangzhou Wenzhong Hospital, China

  • Yue Chen

    Department of rheumatology, Hangzhou Wenzhong Hospital, China

DOI:

https://doi.org/10.30564/jgm.v5i2.6136
Recieved: 29 Oct 2023 | Accepted: 6 January 2024 | Published: 16 January 2024

Abstract

How do you make a diagnosis of lupus encephalopathy (LE) in patients with systemic lupus erythematosus (SLE) concurrent with neurological and psychiatric abnormalities? This is a challenging question. We encountered two cases of SLE associated with LE. One involving the rigidity of the lefs due to extraparamidal vasculitis while the other involved mental illness due to frontal lobe atrophy respectively. The patient in case 2 experienced the attacks of Renault's sign, suggesting a systemic vasculitis. A final diagnosis of LE was established on the basis of elevated concentration of anti-ds-DNA in serum. The authors realized that the neurological or psychiatric symptoms in patients with rheumatic diseases should be carefully recognized in order to avoid a missed diagnosis of LE.

Keywords:

Systemic lupus erythematosus (SLE); Lupus encephalopathy (LE); Anti-ds-DNA; Dysfunction of brain

References

[1] Pasquale, B., Maria, V., Annachiara , M., Carmine, I., & Giuseppe, S. (2020, August 29). Lupus and posterior reversible encephalopathy syndrome. Lupus. 29(9), 1146-1147.

[2] Mathias LM,Stohl W., 2020. Systemic lupus erythematosus (SLE): emerging therapeutic targets. Expert Opinion on Therapeutic Targets. 24(12), 1283-1302.

[3] Muller JH, Jain S, Loeser H, et al., 2008. Lessons learned about integrating a medical school curriculum: perceptions of students, faculty and curriculum leaders. Med Educ, 42(8), 778-785.

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How to Cite

Zhou, M. M., Song, B., Li, G., Peng, Z., & Chen, Y. (2023). Report of Lupus Encephalopathy in Two Patients with Systemic Lupus Erythematosus. Journal of Geriatric Medicine, 5(2), 1–3. https://doi.org/10.30564/jgm.v5i2.6136

Issue

Article Type

Case Report