A Case Report on Canine Transmissible Venereal Tumor

Authors

  • Sagar Regmi Agriculture and Forestry University, Rampur, Chitwan, Nepal
  • Premlal Mahato Agriculture and Forestry University, Rampur, Chitwan, Nepal
  • Iebu Devkota Agriculture and Forestry University, Rampur, Chitwan, Nepal
  • Raju Prasad Neupane Agriculture and Forestry University, Rampur, Chitwan, Nepal
  • Asmin Khulal Agriculture and Forestry University, Rampur, Chitwan, Nepal
  • Anil Kumar Tiwary Departmant of Veterinary Anatomy, Physiology & Biochemistry, AFU, Rampur, Nepal

DOI:

https://doi.org/10.30564/jzr.v2i2.2058

Abstract

A male Japanese spitz (3 years) was brought at Himalayan Animal Rescue Trust (HART), Pokhara with a complaint of swollen gums and loss of appetite. A lobulated tumorous mass was seen at the gingival region on physical examination. Diagnosis and treatment of condition detected in the dog was the major objective. Impression smear of tumor cell was prepared and was observed under oil immersion microscope (100x). Microscopic examination shows the presence of vacuolations within the cytoplasm and the condition was diagnosed to be CTVT. Chemotherapy was performed using the most effective cytostatic agents I.e. Vincristine sulphate (once a week, I/v). The chemotherapy was repeated for 3 doses till the tumor gets completely regressed. The condition was resolved after third session of chemotherapy. Myelosuppression and gastrointestinal effects like vomiting are the major complications of using vincristine.

Keywords:

Transmissible venereal tumor; Impression smear; Cytostatic agents; Vincristine; Myelosuppression

References

[1] Axnér, E., Ström, B., Linde‐Forsberg, C., Gustavsson, I., Lindblad, K., & Wallgren, M. (1996). Reproductive disorders in 10 domestic male cats. Journal of Small Animal Practice, 37(8), 394–401.

[2] Barron, C. N., Saunders, L. Z., Seibold, H. R., & Heath, M. K. (1963). Intraocular tumors in animals. V. Transmissible venereal tumor of dogs. American Journal of Veterinary Research, 24, 1263.

[3] Batamuzi, E. K., & Bittegeko, S. B. (1991). Anal and perianal transmissible venereal tumour in a bitch. The Veterinary Record, 129(25–26), 556.

[4] Beschorner, W. E., Hess, A. D., Nerenberg, S. T., & Epstein, R. B. (1979). Isolation and characterization of canine venereal tumor-associated inhibitory and blocking factors. Cancer Research, 39(10), 3920–3927.

[5] Gilbar, P. J., & Carrington, C. V. (2006). The incidence of extravasation of vinca alkaloids supplied in syringes or mini-bags. Journal of Oncology Pharmacy Practice, 12(2), 113–118. https://doi.org/10.1177/1078155206070448

[6] Higgins, D. A. (1966). Observations on the canine transmissible venereal tumour as seen in the Bahamas. Vet Rec, 79(3), 67–71.

[7] Igor, U., Irena, C., Ksenija, I., Elena, A., Goran, N., & Plamen, T. (2012). Cytological diagnostic of Canine Transmissible Venereal Tumor-case report. Macedonian Veterinary Review, 35(2), 91–96.

[8] Marchal, T., Chabanne, L., Kaplanski, C., Rigal, D., & Magnol, J. t P. (1997). Immunophenotype of the canine transmissible venereal tumour. Veterinary Immunology and Immunopathology, 57(1–2), 1–11.

[9] Murgia, C., Pritchard, J. K., Kim, S. Y., Fassati, A., & Weiss, R. A. (2006). Clonal origin and evolution of a transmissible cancer. Cell, 126(3), 477–487.

[10] Nurgat, Z. A., Smythe, M., Al-Jedai, A., Ewing, S., Rasheed, W., Belgaumi, A., … Aljurf, M. (2015). Introduction of vincristine mini-bags and an assessment of the subsequent risk of extravasation. Journal of Oncology Pharmacy Practice, 21(5), 339–347. https://doi.org/10.1177/1078155214531803

[11] Prier, J. E. (1966). Chromosome pattern of canine transmissible sarcoma cells in culture. Nature, 212(5063), 724–726.

[12] Richardson, R. C. (1981). Canine transmissible venereal tumor. Comp Contin Educ Pract Vet, 3, 951–956.

[13] Rogers, K. S. (1997). Transmissible venereal tumor. The Compendium on Continuing Education for the Practicing Veterinarian (USA).

[14] Science, V. (2015). Veterinary science, 2, 109–117.

[15] Solution, P. F. (n.d.). VinCRIStine Sulfate Rx only, 1–9.

[16] Spugnini, E. P., Dotsinsky, I., Mudrov, N., Cardosi, G., Citro, G., D Avino, A., & Baldi, A. (2007). Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model. Journal of Experimental and Clinical Cancer Research, 26(4), 483.

Downloads

Issue

Vol. 2 , Iss. 2 (April 2020)

Article Type

Articles

License

Copyright and Licensing

The authors shall retain the copyright of their work but allow the Publisher to publish, copy, distribute, and convey the work.

Journal of Zoological Research publishes accepted manuscripts under Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). Authors who submit their papers for publication by Journal of Zoological Research agree to have the CC BY-NC 4.0 license applied to their work, and that anyone is allowed to reuse the article or part of it free of charge for non-commercial use. As long as you follow the license terms and original source is properly cited, anyone may copy, redistribute the material in any medium or format, remix, transform, and build upon the material.

License Policy for Reuse of Third-Party Materials

If a manuscript submitted to the journal contains the materials which are held in copyright by a third-party, authors are responsible for obtaining permissions from the copyright holder to reuse or republish any previously published figures, illustrations, charts, tables, photographs, and text excerpts, etc. When submitting a manuscript, official written proof of permission must be provided and clearly stated in the cover letter.
The editorial office of the journal has the right to reject/retract articles that reuse third-party materials without permission.

Journal Policies on Data Sharing

We encourage authors to share articles published in our journal to other data platforms, but only if it is noted that it has been published in this journal.