Investigating the in vitro Antitumor Structure-activity Relationship of a Range of Cannabinolic Acid Derivatives

Authors

  • Alexander Aizikovich AL & AM Pharmachem Ltd. Carmel St. 5, Rehovot, Israel

DOI:

https://doi.org/10.30564/jor.v5i1.5115

Abstract

Aim: To investigate the in vitro structure-activity relationship (SAR) of a range of tetrahydrocannabinolic (THCA) and cannabidiolic (CBDA) derivatives using the PANC-1 tumor cell line (pancreas, ductal carcinoma). Materials and methods: The in vitro effects of a range of THCA and CBDA derivatives with different carbonyl group substituents were tested on the PANC-1 cells cell line using the CellTiter Glo Viability Assay (72 hours) and the XTT assay (48 hours). Results: A study of a series of THCA and CBDA derivatives containing different functional groups at the carbonyl nitrogen atom demonstrated that THCA amides have better inhibitory activity, on the PANC-1 tumor cell line, than CBDA derivatives. Conclusions: THCA derivatives have better inhibitory activity than CBDA analogs with the same substituents. It is noteworthy that even a slight change in the structure of the substituent of the amide or hydrazone moiety of the molecule has a dramatic effect on the activity of these compounds.

Keywords:

THCA; CBDA; PANC-1; SAR

References

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How to Cite

Aizikovich, A. (2023). Investigating the in vitro Antitumor Structure-activity Relationship of a Range of Cannabinolic Acid Derivatives. Journal of Oncology Research, 5(1). https://doi.org/10.30564/jor.v5i1.5115

Issue

Vol. 5 , Iss. 1 (January 2023)

Article Type

Articles

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