Journal of Oncology Research

Abstract:

Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed. Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymine T₃*, adenines A₂* and A₄* so that between them hydrogen bonds are formed. Canonical adenine and cytosine can be incorporated opposite canonical thymine only. Canonical thymine and guanine can be incorporated opposite canonical adenine only. If in the synthesis of DNA containing rare tautomeric forms of thymine T₃*,... More

Abstract:

About 15.4% of human cancers worldwide have been attributed to infections. Among these, blood and liver flukes, notably Schistosoma sp, Clonorchis Sinesis, and Opisthorchis Viverrini have been associated with the development of various cancer types. Schistosoma sp. promotes colorectal cancer (CRC) progression through multiple mechanisms including production of toxins, symbiotic action with bacterial agents, and more importantly chronic inflammation. Diagnosis... More

Abstract:

Background: Both of UFT-/Tegafur-based postoperative chemotherapy and postoperative radiotherapy have made large progress in treatment of early-stage non-small cell lung cancer. While it is unclear that, whether UFT-/Tegafur-based postoperative chemotherapy is superior to postoperative radiotherapy for early-stage non-small cell lung cancer with no direct evidence. Methods: Electronic databases (Pubmed, embase, cochrane library and clinicaltrials.gov) were searched to... More

Abstract:

Cancer stem cells (CSCs) are a subpopulation of tumor cells with properties of self-renewal, pluripotency, plasticity, and differentiation, and are associated with various aberrantly stimulated signaling pathways. They are responsible for tumor recurrence, distant metastasis, and drug resistance, thus inducing poor prognosis. Immunotherapy has achieved encouraging results. However, the resistance associated with its clinical application... More